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Compressibility of tablet material

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Compressibility of tablet material

Compressibility refers to whether the material is easy to compress into sheet performance. The formability of the material can be evaluated by hardness, tensile strength and elastic recovery rate of the tablet. The tablet should be of the right hardness and should also ensure that the tablet disintegrates quickly or that the drug dissolves too quickly. When the content of the main drug in the tablet is small, pharmacy method should be used to achieve the purpose of uniform distribution of the drug, under normal circumstances, it is appropriate to use simple excipients; When the content of main drug in tablets is large, attention should be paid not only to the fluidity and compressibility of excipient, but also to its capacity and the amount of excipient, and also to the influence of particle size and form of active ingredient on the compressibility.

Compressibility is related to the plasticity and elasticity of raw materials and the microscopic state of material particles. Microcrystalline cellulose has a spongy dolly, tubular structure, easy to deform, so it is commonly used as a dry adhesive with good compressibility. In general, when the amount of microcrystalline cellulose is 5%, the hardness of the tablet can be increased. If the hardness of the tablet is the main issue in the production, the first consideration is the use of microcrystalline cellulose, which can be as high as 65%. However, when several excipients are used together, the compressibility will change. For example, when lactose and microcrystalline cellulose are used together, the additive effect will occur. When sucrose powder and microcrystalline cellulose are mixed, the antagonistic effect is produced.

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