Testing requirements for blister packaging The main packaging object of blister packaging is solid drugs. The packaging should isolate the drug preparations contained in the packaging from the outside world, so as to prevent the volatile, escape and leakage of the active ingredients of the drug on the one hand. Volatile pharmaceutical ingredients can be dissolved in the inner side of the packaging material and spread to the other side under the action of osmotic pressure, such as solid pharmaceutical preparations containing aromatic ingredients and endogenous volatile active ingredients, whose active ingredients are volatile and penetrate some materials. On the other hand, it can prevent the outside air, moisture, foreign matter and microorganisms from entering and contacting with the drug. The air contains oxygen, water, a large number of microorganisms and foreign matter particles, these components into the packaging will lead to oxidation, hydrolysis, degradation, contamination and

Blister packaging molding According to the principle that P V C film (hard sheet) is heated through the mold and is formed into the desired shape and size by compressed air or vacuum, the following aspects should be solved when there are problems in the formed bubble caps (1) Whether P V C film (hard film) is qualified product; (2) whether the temperature of the heating device is too high or too low; (3) whether the surface of the heating device is adhering to P, V and C; (4) whether the forming mold is qualified, whether the forming hole is smooth and whether the pores are unobstructed; (5) Whether the cooling system of the molding mold works normally and effectively; (6) the vacuum degree and exhaust rate of the roller negative pressure forming can reach the normal value, and the pipeline has no abnormal loss; (7) whether the compressed air formed by plate positive pressure is clean and dry, whether the pressure and flow can reach the normal value, and whether the pipeline ha

Blister packaging technology Blister packaging, also known as Blister Packaging Eye, or PTP (Press ThroughPackaging) packaging technology, is one of the rapidly developing forms of drug packaging in recent years. PTP technology to heat and soften the plastic film and placed in the mold, or blow compressed air through a vacuum pump, so as to form blister medicine eyes, and then coated with glue aluminum foil medicinal under certain temperature and pressure conditions sealed to form a blister packaging. At present, pharmaceutical blister packaging has become the mainstream of tablet, capsule, pill and other solid dosage form packaging, the development momentum will continue. Blister packaging in our country the status quo of drug along with our country reform and opening-up and the deepening of the medical and health system reform, especially after China's entry into the WTO, the international pharmaceutical companies greater access to China, China's pharmaceutical industry competition,

Blister packaging process The cavity of the blister pack is large or small, and its shape is different due to the shape of the packaged goods. There are some that are available and some that are not. And the type of blister packing machine is also more. Nevertheless, the basic principle of blister packaging is roughly the same, and its typical process is: sheet heating → film forming → filling product → placing substrate → heat sealing → trimming and trimming. The above process can be completed by manual operation, semi-automatic operation and automatic operation. 1. Manual operation. Plastic sheet blister pre-forming, substrate pre-printing drama and cutting; When packing, manually put the product into the bubble cap, cover the substrate, and then seal the bubble cap and the substrate together with a heat sealing clamor. Some products on the circulation environment temperature and humidity requirements are not high, can not be heat sealing, and stapler stapling. 2. Semi-autom

Material requirements for pharmaceutical blister packaging Drug blister packaging is directly in contact with the drug, and some drugs need to be stored for a long time, the quality of drug packaging is directly related to the quality of the drug, involving the health and safety of the person. Therefore, the requirements for pharmaceutical packaging are as follows: (1) Packaging materials should be non-corrosive, and have insect, moth-proof, microbial inhibition and other properties, in order to protect product safety. (2) packaging materials should have good barrier performance. Packaging materials should be moisture, water vapor, gas, light, fragrance, odor, heat and so on with a certain barrier. (3) packaging materials should be suitable for processing, convenient for the mechanization and automation of packaging operations, in order to adapt to large-scale industrial production should be suitable for printing, easy to print packaging marks. (4) the packaging material

The importance of thermal bonding strength to blister packaging Blister packaging, also known as blister packaging or PTP packaging, is made by placing tablets or capsules in a blister or blister eye of a hard piece, and then hot-bonding the hard piece with aluminum foil. As the surrounding area of each bubble eye is the thermal bonding area formed by hard pieces and aluminum foil, each bubble eye is independent of each other, and the damage of one bubble eye will not affect the sealing integrity of other bubble eyes. Therefore, each pill or capsule in the bubble wrap package has little influence on each other, less interference, and the chance of contamination is reduced. In addition, blister packaging also has the characteristics of high barrier, good sealing, good hygiene performance, etc., has become an inseparable part of the pharmaceutical packaging field, and gradually extended to the food, health product packaging field. If it is not hard to see from the above analysis, t

Blister packaging update It is predicted by the relevant department in the UK that blister drug packaging will have a big change in packaging form in the future, and other drug packaging forms such as container packaging will also be gradually transferred to blister packaging. Therefore, in order to get a better development of drug packaging, we must find out the current trend of the development of society, to ensure that China's drug packaging and the current form of packaging, so as to be further developed. Blister packaging can be updated from the following aspects. Make sure the package matches the efficacy of the product. Prevent drug failure due to faulty packaging. Ensure the convenience of medication for patients: Manufacturers should improve the convenience of medication for patients in memorized drug packaging. Unique security packaging. That is, to ensure that the pharmaceutical packaging is corresponding to the development of medical technology, while ensuring the uni

The development level of blister packaging in China needs to be improved Although the level of blister packaging has developed rapidly in China, the types of packaging have been increasing year by year. However, for developed countries, there is still a certain gap. The main reasons for the gap with developed countries are: 1. China's overall pharmaceutical production technology is relatively low. Compared with developed countries, China has fewer pharmaceutical equipment, which restricts the development of pharmaceutical packaging. 2. Due to the large dosage of drugs, it is difficult to increase the service of blister packaging for drugs taken in large doses. The production cost of blister packaging is higher than that of bottle packaging in larger doses, which is not conducive to the realization and promotion of blister packaging in China. Therefore, in order to increase the use and promotion of blister packaging, manufacturers can reduce the drug dosage, and improve the acc

Foreground of blister packaging In the process of blister packaging, packaging materials, production equipment and other aspects still need to further accelerate the development of drug blister packaging, and further strengthen the quality and service quality of Chinese pharmaceutical packaging, as in other countries in the world. 1) Adequately and effectively protect the drug. As with any form of protective drug packaging, ensuring the effectiveness of the drug remains a basic requirement of blister packaging. 2) Safe and convenient to use. Develop safe packaging suitable for children and packaging suitable for the elderly to facilitate children and the elderly. 3) Unique anti-counterfeiting packaging. The safety of diversified blister packaging materials achieved by new technology not only reflects the personality of drug packaging, but also protects enterprises and brand products. 4) Green packaging. Blister packaging vigorously developed and promoted, biodegradable, not pollut

Development of blister packaging materials for adhesives At present, aluminum foil coating adhesive is mainly composed of one - component and two - component adhesive. Glue is mainly composed of natural glue or synthetic glue and acrylic acid composition, because it is mainly elastomer, plus viscosity additives and organic solvents mixed with emulsion, with strong thermal solubility, strong adhesion and other characteristics. As health requirements increase for pharmaceutical packaging materials, the use of newly produced single-component adhesives is gradually decreasing, and mainly two-component polyurethane coatings. The main mechanism of the adhesives is the master agent and the fixative agent, which usually contain many active hydrogens, such as hydroxyl, amino hydrogen and other substances solidified composite isocyanate vinegar. The addition reaction occurs automatically when it comes into contact with the active hydrogen of the main molecule of the chemical reagent, formi