What are the ways of capsule filling

What are the ways of capsule filling

Most of the capsule filling machines in China are standard quantitative filling machines. The filling volume is determined by the thickness of the measuring plate and is related to the loose density of the filling material. At the same time, the accuracy of filling quantity control is related to the factors affecting the filling structure and the filling material itself.

Filler material moisture absorption are factors that influence the control capsule filling accuracy when filling powder or particle viscosity high humidity is too large, illiquid, viscosity phenomenon of metropolitan produce plug powder, powder refers to a certain filling rod pressure measurement plate hole under powder cylinder cannot be pressed out phenomenon, powder filling usually any drug mixed filling process of powder or granule, humidity below 4%. In addition, the moisture absorption capacity of the filler is related to its critical relative humidity. Generally speaking, when the purity of bottling powder or particle is not high, its critical relative humidity is lower, and its multi-component will also increase the hygroscopicity. Both thicken the filling process, increasing the volume of the cargo and making buffering easier. Too much water absorption can also render a drug ineffective. Therefore, in the process of filling, the environmental humidity should be controlled under its critical relative humidity, the corresponding relative humidity varies with the different drugs, such as penicillin < 47% is good, aminoglycoside < 58% is good. But the capsule also has certain humidity requirements. Due to the low humidity of the cyst, it is easy to rupture. Therefore, the overall filling environment humidity of the cyst should be controlled within 40-60%.

The filling method of capsule filling machine has two main principles, one is piston filling, the other is feeding disc filling. Different filling methods have different prescription requirements. Piston filling requires a good flow rate of powder to ensure that the powder column is fully ejected. In addition, the powder must have good pretension to ensure that the tower is not easily broken when removed from the powder bed.

The filling of the dosing tray also requires sufficient lubricant to facilitate the compression of the column of powder, thereby avoiding film overlaying and reducing friction between the sliding parts. At the same time, the powder must also have the stamping ability, in order to punch out a good forming powder column, but this stamping ability is not as strict as the requirements of the plunger packaging. The filling of dosing tray requires good fluidity of powder, which is also reflected in the use of powder to ensure uniform distribution of dosing tray, thus ensuring uniform filling.