The mechanism of rotary tablet press Rotary tablet press is a machine which is made up of several pairs of punch dies distributed on the turntable and moving up and down in a circle according to a certain track, and presses granular materials into tablets through the press wheel. And punch with the linear velocity of the turntable rotate more than 60 m/min called high-speed rotary tablet press machine, the high-speed rotary tableting machine has forced feeding machine, the machine is controlled by PLC, automatically adjust the pressure, control weight, eliminate waste pills, print data, display downtime, and other functions, in addition to can control weight difference in a certain range, quality problems such as lack of Angle, loose lobes can automatically identify and eliminate. The shape of the tablet pressed by the tablet press was initially oblate and then developed into shallow and deep circular arcs on the upper and lower sides, which was for the need of coating. With the

Weight difference between tablets by tablet press The Chinese Pharmacopoeia has specific regulations on the weight difference of tablets. If the weight difference is large, the content of the main drug in the tablets will be affected. In order to ensure that the weight difference of tablets meets the requirements of the Chinese Pharmacopoeia and avoid producing unqualified products, strict weight difference control method is often adopted when the tablets are pressed, that is, when the tablets are pressed, sampling inspection is conducted at certain intervals to check whether the extracted samples are within the prescribed limit. Generally speaking, the weight difference of tablets is mainly due to the large difference in particle size, the flow rate of particles is different when pressing tablets, so that the particles fill the mold hole is not uniform. In this case, too much fine powder can be sifted away, or re-granulated. In the production of tablets, in addition to the above

Structure of Forced Feeding System of Tablet Press At present, most of the forced feeding system of the tablet press mainly consists of three parts, which are introduced as follows: (1) the hopper part, mainly plays the role of storing materials, and the lower part is connected with the forced feeder; (2) Reducer motor part, is the power source of the forced feeding system, mainly including three-phase/single-phase motor and worm gear reducer, controlled by frequency converter, the output speed is adjustable, the lower part and the forced feeder connection; (3) the forced feeder, the main role is to fill the material to the rotary table in each die hole, by its completion of the final mission of the forced feeding system, so the forced feeder is the core component of the entire forced feeding system. Forced feeder structure is mainly the use of gear meshing to reduce the one-way rotation of the motor into the reverse rotation of the two dial impeller, the use of dial imp

Tablet press for the requirements of drugs The drugs for powder direct tablet should have a certain thickness or crystalline form; Drug powder should have good fluidity, compressibility and lubricity. But most drugs do not have these characteristics, which can be solved by improving the performance of drugs. For example, when the thickness and crystalline morphology of the drug are not suitable for direct tablet pressing, it can be improved by appropriate means, such as changing the particle size and distribution, changing the morphology, etc., such as recrystallization method, spray drying method, etc., but there are many difficulties in actual production and it is seldom used. Low-dose drugs (such as the main drug content in 50 mg or less), the prescription contains more excipients, its mobility, compressibility, lubricity mainly depends on the performance of excipients. No matter the fluidity and compressibility of the drug itself is good or bad, it can be directly pressed aft

Tablet press production operability Reasonable prescription should be suitable for mass production. It should not only meet the production conditions, such as the tablet speed and pressure, but also meet the quality standards of tablets, such as the phenomenon of non-viscous impact, sliver and loose tablets. The hardness, disintegration, dissolution, tablet weight difference and tablet thickness of tablets should all meet the requirements. Only the tablet speed is faster, to improve output, improve labor productivity; Only by reducing the pressure of the tablet press can the loss of the tablet press and the die be reduced and the service life be extended. Sometimes small test or short time production, there will be no adhesive impact, sliver, sheet weight and other abnormal conditions, but for a long time production, these abnormal phenomena will be revealed. In this case, the prescription should be adjusted to solve the problem. In the design of specific varieties, trial production

Disassembly of die of tablet press (1) disassemble the upper punch Loosen the upper punch fastening nut, you can pull out the upper punch rod. If it is tight, you can pull it out by clamping the upper punch rod with hand tongs, but pay attention not to damage the punch shuttle blade. (2) remove the middle die Loosen medium die setting screw. Unscrew the down drive set screw, loosen the adjusting screw and loosen the gear press. Turn the adjusting gear to make the lower punch core lever rise about 10 mm, gently turn the handwheel to make the lower punch core lever push out part of the middle die, take out the middle die by hand, if the middle die is tightly aligned in the hole, do not force to turn the hard top of the handwheel to avoid damage to the parts. At this time, the middle die plate must be removed before taking out the middle die. (3) disassemble the bottom flush First, screw down the punch fixing screw, and then turn the hand wheel to make the punch core rod

Prescription design of tablet press Compressibility: Compressibility refers to whether the material is easy to compress into pieces. The formability of the material can be evaluated by hardness, tensile strength and elastic recovery rate of the tablet. The tablet should be of the right hardness and should also ensure that the tablet disintegrates quickly or the drug dissolves quickly. When the content of the main drug in the tablet is small, pharmacy method should be used to achieve the purpose of uniform distribution of the drug, under normal circumstances, it is appropriate to use simple excipients; When the content of main drug in tablets is large, attention should be paid not only to the fluidity and compressibility of excipient, but also to its capacity and the amount of excipient, and also to the influence of particle size and form of active ingredient on the compressibility. Compressibility is related to the plasticity and elasticity of raw materials and the microscopic state

Tablet press filling instability how to do? Instability of filling will lead to tablet difference. Tablet difference means that the weight of tablet exceeds the allowable range of tablet weight difference prescribed by the pharmacopoeia. The causes and solutions are: (1) the particle fluidity is not good, the amount of particles flowing into the die hole is more or less, resulting in a large difference in sheet weight, should be re-granulated or added better flow aid such as micro powder silica gel, etc., to improve the particle fluidity; (2) too much fine powder or particle size difference, resulting in the flow into the mold hole when the material is heavy and light, should remove too much fine powder or re granulation; (3) the particles in the hopper are more or less, and the weight fluctuation caused by the feeding will also cause the sheet weight difference to exceed the limit, so there should always be more than 1/3 of the particles in the hopper; (4) punch and die

Causes and treatment of explosive punch of tablet press The causes and treatment of detonation are as follows: Punch burst and missing Angle, metal chips may be embedded in the tablet. Due to improper heat treatment of the punch, it has damage and cracks without careful examination, can not withstand pressure or too much pressure of the tablet press, and can cause explosive impact when pressing crystalline drugs. The heat treatment method of punch should be improved, the quality of punching die should be checked, the pressure should be adjusted, and the appearance of tablet should be checked. If a detonation is found, the debris should be searched immediately and the cause identified to overcome it. The causes and treatment of the fault thrust are as follows: Fracture of punch or punch neck. Due to improper heat treatment of the die, there are damage cracks in the die without careful inspection, the pressure of the press or the tablet press is too large, and the fatigue lim

Type of die for tablet press There are many kinds of die, but we can distinguish them according to the different equipment, materials, standards and shapes used 1.1 According to the different equipment used, there are single punching die, rotary punching die, flower basket punching die and press punching die; 1.2 according to the different materials made, there are alloy steel die, carbide die, ceramic die, chromium plating, titanium plating die; The most common alloy steel materials for domestic die are: GCr15, CrL2MoV, CrWUMN, 9Mn2V, 9CrSi; The most common materials for imported die are: A2, O1, S1, S7, PHG.S, PHG-P. 1.3 According to different standards, there are ZP standard (GB12253.90) die, IPT international standard die, EU standard die and various non-standard special tablet press die and battery ring die; (High speed tablet press die standard JB/T20080.1-2006 (T series recently passed the joint examination) single stamping die tablet press because of its standard an