The direct and auxiliary materials of the tablet press
The difference between direct and wet granulation is that the material required for the presser is fine powder in powder form, and the presser and fluidity of the material will determine the quality of the final product. Since the fluidity and compressibility of all kinds of drug powder cannot meet the requirements of direct tablets, it is one of the most direct and effective ways to improve the fluidity of drugs to select the auxiliary agent with superior performance. Compared with wet granulation, the correct selection of auxiliary materials in direct stamping process is more strict. However, traditional excipients do not combine good fluidity with excellent compressibility, adhesion, high adhesion and low sensitivity to lubricating oil to meet the requirements of direct compression. The traditional starch, dextrin and sugar powder have poor fluidity and compressibility. Therefore, it is a new topic to develop auxiliary materi
Operation of capsule filling machine
Structurally, the top of the rotating cylinder is a large, empty capsule can; At the top end of the rotating barrel, there is an external feeding tube, and the bottom of the feeding tube is equipped with a door to control the exit of the capsule. There is an internal fork close to the rotating cylinder and an external closing lever. A measuring tube is installed in the inner layer of the tube. The measuring tube moves vertically according to the curve of the CAM groove in the tube, and the rotation of the tube is simplified. The lower flange of the drum is equipped with an upper support fixed mold corresponding to the number of feed tubes to limit the cap body to fall off when the empty capsule is opened, leaving the cap body in the mold on the upper support. Above the flange is the positioning device to complete the inverted capsule. Below is the lower support mold of the capsule body, in addition to the simple rotation motion, but also accordin
Blister packaging machine process
Under the mold base and mold are fixed connection on the stand together, and on the mold in the rotation of the CAM driven by vertical movement, when the upper and lower die together, through the channel of mold base to the cavity into the compressed air blowing, aluminum-plastic film under the action of compressed air blown into the blister, plate type blister packaging machine adopts plate heat sealing method, on the sealing plate with heater, sealing up and down a checkered plate, due to the plate sealing contact area is large, in order to under pressure in a given system can sealing strong, so the sealing plate coated with pressure cylinder, the work, the sealing plate, the sealing plate under the action of the up and down along the vertical direction, complete sealing function.
Cutting is at the end of a process, it is bring continuous forming membrane sealing printed according to the preset number and arrangement form into fixed single plat
The stamping of sheet pressing machine
Compared with wet granulation, direct crushing technology also has the advantage of avoiding the influence of humidity and heat. In practical application, some drugs with unstable chemical properties, such as esters, starch, hydroxyl, phenols, vitamin C and vitamin E, are easy to be hydrolyzed. During wet granulation, many drugs that are unstable under the action of light and heat may undergo hydrolysis reactions, or may be destroyed by heat during particle drying, or may be due to complex processes that lead to the photosynthetic breakdown of the drug. In order to solve these problems, direct stamping process can be considered. Due to the simple process of direct powder pressing, no need for granulation and drying, it can effectively protect the stability of major drugs and avoid various unstable factors caused by wet granulation, thus ensuring the quality of products.
Some of the drugs produced have a low melting point, after the drying of
Development of capsule filling machine
Capsule filling machine is a special capsule filling equipment in pharmaceutical industry. It is also an important pharmaceutical equipment such as pharmaceutical factory, health product factory and hospital preparation room. With the advent of the mechanized age and the beginning of the industrial age, capsule filling is increasingly on the road of automation, automatic capsule filling arises at the historic moment.
As is known to all, China's filling capsules are not as good as foreign products in terms of production speed, production accuracy, equipment operation stability, etc., especially in the aspects of preparation machinery and packaging machinery, we are quite different. Therefore, China's pharmaceutical machinery enterprises need to constantly strengthen technical innovation to promote the development of automatic capsule filling machine.
The rapid development of industrial scale production in recent years, under the steady nat
Blister packaging machine plate brush feeding
Blister packaging machine, including transport system and between the transport system is set up to protect the most important system of protective barriers, a transportation system, medicine plate activity configuration on the wall on either side of the roller, the corresponding list mentioned in the various kinds of holes on the blackboard, the groove of the hole and the medicine plate one-to-one correspondence, in vertical fixed protection has some brush, brush the rotation of the motor, this paper introduces the through the duct connected to the storage of the pot, the configuration output port are aluminum-plastic film, bubble film, adhesive between the diaphragm.
Existing blister machine placed in drugs, especially the panels set scraper, through scraping board drugs into the groove, when grooves around just have agents can realize the medicament into the slots, otherwise not from drugs into some of the slots, leading to can't e
Powder pressing process
Direct powder production technology has excellent disintegration and dispersion properties and excellent uniformity, so now, this technology is widely used in some fast release tablets, tablets manufacturers are also more and more use direct powder technology.
Why can the direct powder tablet process improve the disintegration of tablets? Experts explain that the breakdown of the drug depends on the pill dissolving through capillaries or swelling. The tablets prepared by the direct crushing method and the tablets prepared by the wet method have different disintegrating agents, which will not reduce the disintegrating performance due to contact with the tablets prepared by the wet method, thus ensuring good disintegrating characteristics. In addition, due to the lack of pills, pills will not be decomposed into large particles, but the fine powder has a large specific surface area, which can be evenly distributed and increase the body's dependence, leading t
Maintenance of capsule filling machine
Equipped with microcomputer programmable controller, different operation speed through touch screen panel, equipped with electronic automatic counting, can realize the positioning of the capsule, the automatic separation and locking of the capsule packing, reduce labor intensity, improve production efficiency, meet the requirements of medical and health.
Within a short time at each station, it can automatically complete all kinds of operations, such as sowing, dividing, filling, waste bag removing, locking, releasing, mold cleaning, etc.
Suitable for all kinds of domestic or imported capsule filling. It is the most economical and practical drug capsule filling equipment in the pharmaceutical industry.
The device is a vibration motor, and the screw fixation of each component should be checked frequently. If it is loose, it should be tightened in time to avoid damage.
Plexiglass components should avoid high temperature direct sunlight
Cleaning and finishing of blister packaging machine
Remove the waste PVC and aluminum foil rolls used by the blister packaging machine according to the installation procedure and collect them into the waste drums.
Unscrew the nut on the indentation plate, remove the indentation cover plate and place it on the operating table, unscrew the module fixing nut, wipe it clean with alcohol, then screw the nut and indentation cover plate back in order.
Clean the scraps scattered on the surface of the machine with a brush, collect them into the waste bucket, and wipe the surface of the machine clean with a wet cloth.
Wash and seal the upper and lower surfaces of the heating plate with steel wire brush twice a month.
After cleaning the special greasy spot, remove the residual detergent with a clean wet cloth and wipe it with a dry cloth.
Before starting each time, check whether the pressure of compressed air reaches the normal state, check whether the chiller works normally, ch
Preparation method of tablets
The preparation methods of tablets include wet granulated tablets, dry granulated tablets, powder direct tablets and freeze-dried tablets, etc.
Direct powder tablet means that the powder is directly pressed into tablets, separately screened, mixed with appropriate excipients, without wet granulation or dry granulation direct tablet. Because the technological process is simple, no need to granulation and drying, save energy and time, protect the stability of drugs, improve the solubility of drugs, achieve a high degree of industrial automation, more and more domestic pharmaceutical companies used. Data show that about 40 percent of overseas tablet varieties are produced through a single process. Compared with traditional wet granulation, the most obvious advantage of direct crushing technology is economy. In traditional wet granulation, the amount of adhesive, the drying time of the granule and the screening time of the alcohol granule must be conside