Dose control of tablet press Different tablets have different dose requirements, and large dose adjustment is achieved by selecting different punch diameters of the die. After selecting the size of the die, the small dose adjustment is to change the actual length of the die hole after the back cover by adjusting the depth of the down punch into the die hole, so as to achieve the purpose of adjusting the filling volume of the drug in the die hole. Therefore, the tablet press should have a mechanism to adjust the original position of the punch in the die hole to meet the requirements of dose regulation. Control tablet thickness and degree of compaction The dosage of the drug is determined according to the prescription and pharmacopoeia and cannot be changed. Dosage pressure is also required for storage, storage and disintegration, which will affect the actual thickness and appearance of the tablet. Pressure regulation during tablet pressing is essential. This is achieved by adju

Tablet press selection reference In recent years, many tablet manufacturers have gradually approved the high-speed rotary tablet press from trial, and there is a tendency to replace the high-speed rotary tablet press. To explore the reasons, I believe that as long as there is a general understanding of the high-speed rotary tablet press people will say that the advantage is small, high efficiency, energy saving, the province of occupation, high information level. Taking the high speed rotary tablet press of our company as an example, a brief analysis is carried out around the cost performance, for the reference of the user selection. (1) High output. The output output of the high-speed rotary tablet press is 4 ~ 5 times that of the low-speed rotary tablet press for the same diameter and similar number of die presses. Namely in the same time to complete the same output, is the number of high-speed rotary tablet press and 4 ~ 5 sets of low speed rotary tablet press relationship.

Insufficiency of tablet press equipment Although the performance of domestic tablet press equipment has been greatly improved, there are still many shortcomings in practical application: (1) the structure of the machine still needs to be improved, such as the tablet press maintenance needs to use lifting tools, manual lift the rotary table, disassembly time-consuming and laborious. And some foreign advanced tablet press, using the structure of the rotary table, up, down and track can be moved out with the rotary table, greatly shorten the time to change the mold, repair the machine; (2) the gap in machine performance. For example, when pharmaceutical factory uses 28 stamping machine, in the case of pressing special-shaped sheet, because the pressure needs to be adjusted higher, the spindle strength is not enough, the situation of breaking. This kind of spindle is hollow shaft, the reason that causes the break, has the design defect, also has the processing problem; (3) Equi

Selection of tablet press According to the production process and quality requirements of drugs, the selection of tablet press is mainly from the following aspects: (1) According to the characteristics of powder and particle, choose the appropriate tablet press (mainly Chinese medicine or western medicine, the composition proportion of raw and auxiliary materials, etc.); (2) Determine the output of equipment according to capacity and reserved capacity; (3) select the appropriate charging system according to the existing process; (4) According to the production record and deviation, equipment maintenance frequency and equipment control points in the production process of the product in the past; (5) the operation is convenient, reliable, there is a necessary adjustment device. Such as mechanical regulating device, filling regulating device, pressure regulating device, speed regulating device, sheet thickness regulating device, etc (6) The design of the tablet pressing room should

Tablet press die manufacturing Manufacturing of punching die. In die manufacturing technology, in addition to the choice of reasonable and affordable conventional processing means, whether the effective control of quality characteristics of the important items of precision, professional vacuum heat treatment technology is the most important means. Vacuum heat treatment is an advanced heat treatment technology with high efficiency, high quality, energy saving, clean and pollution-free and programmed control. One large can improve plate shape is the feature of surface hardness and surface brightness, and other related aspects of the surface quality and performance, such as fatigue and corrosion resistance, and have to improve the plasticity, toughness and fatigue strength of parts, small parts deformation, reduce artificial factors affecting the quality, etc., is a high quality tablet in the process of the die manufacturing indispensable key technology. Our company has applied advanced

Die design of tablet press Design of pressing die for tablet. The design of pressing die should not only properly coordinate the selection of association, such as the punching body of the upper and lower punching rod and the punching rod hole, the outer diameter of the middle die and the middle die hole, the lower punching rod and the filling protection guide rail, the punch and the inner hole of the middle die, but also make the forming tablet safely exported. In addition, special attention should be paid to the shape design of the die. For the manufacturers of tablets, the focus is mostly on the degree of convenience for patients to chew or swallow the tablets, improving the therapeutic effect and the appearance of the tablets. As a tablet die manufacturer, it is an important part of our work to design a die that meets the needs of customers. In order to ensure its service life, die design usually follows three design principles: beautiful shape, smooth release and high bearing

Automatic detection of tablet press Automatic testing of tablet press is of great significance to ensure the quality of products. Some advanced tablet press has been able to achieve the preloading, the main pressure, average pressure, single die pressure values, packing depth and preloading into mould into depth and the main pressure on depth, preloading slice thickness, main tablet thickness, rotary speed and timely on-line automatic detection, the machine in the operation of each process, are in a state can be measured and controlled. The application of PAT process analysis technology, the production of various key parameters timely measurement, timely adjustment, timely correction of deviation, can ultimately ensure the quality of products. For example, according to the pressure feedback information in the tablet press to judge the unqualified tablets, remove the waste tablets. The tablet samples were randomly selected, the weight, thickness and hardness of the tablet were detect

Control material discoloration of tablet press Control the noise of the material itself. Due to the imperfect granulating and drying process, or the cleaning of mixing and conveying equipment is not in place, it is easy to lead to the formation of mixed color material particles. Prevent chemical reaction of materials. Some parts of the tablet press that are in direct contact with the material, such as feeding substrate, scraping plate, powder collecting ring, scraping sheet and retaining sheet, are often made of corrosion resistant bronze material. For the special formula materials that are easy to change color due to chemical reaction with copper parts, such as inosine tablets and other tablets, the material of the relevant parts should be replaced before the test for more stable performance of austenitic stainless steel. Prevent material friction heat discoloration. The high-speed rotary table of the tablet press moves relative to the contact material parts such as the subst

Powder running improvement of tablet press In the process of tablet production, tablet pressing is the process of forming the material. Tablet pressing process can be briefly summarized as follows: the powder material from the hopper into the forced feeding mechanism; The cloth impeller of the forced feeding mechanism will cloth the material into the middle plate (also known as the main rotary table) in the die hole; Upper and lower punch with the central disk rotating at the same time, by the upper and lower guide rail curve groove, a smooth curve and exercise, after filling, preloading, main pressure, the four stations, after scraping powder area, preloading area, the main pressure zone, the area, remaining material recycling cleaning area, form a circle, the material crushing and continuous tablet is the cycle of repeated. At present, the key components of the domestic high-speed tablet press, such as the hopper, the forced feeding mechanism, the middle plate, etc., are indepe

Fatigue fracture of pressing die of tablet press The punching die of the tablet press is a part of repeated motion, so the probability of fatigue fracture exists. Once the die breaks in the work, the consequence is very serious. Therefore, the fatigue fracture of the die should be strictly prevented. We know that the fatigue fracture of steel has a development process of crack formation, expansion and fracture, and the fatigue fracture formation stage generally accounts for 70%~80% of the fatigue life. Therefore, preventing the premature formation of fatigue crack is the key to improve fatigue fracture. Fatigue fracture is the part under the action of cyclic load, starting from some weak links, the weak links of the punching die is in the punch arc transition which is easy to produce stress concentration, to prevent the formation of fatigue crack, the first is the selection of the punching die, that is, the punch and the punch body of the arc can not be too small; Secondly, the r