Adjuvants in tablets

Adjuvants in tablets

The most commonly used adjuvants in tablet preparation are fillers, thinners, adhesives, lubricants and disintegrants.

Diluents and adsorbents, collectively known as fillers, are used to increase the weight and volume of a tablet. If the drug itself is sticky, particles can only be made by adding a wetting agent. The most common fillers or thinners are starch, powdered sugar, dextrin, cream, compressible starch, microcrystalline cellulose, and inorganic salts.

Some powder itself is not viscous or low viscosity, need to add a sticky substance, such as starch paste, to bond together. Commonly used adhesives: ethanol, starch pulp, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose;

In addition to oral, sublingual, palliative, and controlled-release tablets, a disintegrating agent is often required. These tablets need to be dissolved and released slowly. Common disintegrating agent: dry starch, carboxymethyl starch sodium.

To increase the fluidity of powder or glue, reduce their friction, prevent adhesion, promote the glue out of the hole, out of the mold, do medicine out of the tablet to be bright and beautiful. Common lubricants: magnesium stearate, silica powder, talc powder, hydrogenated vegetable oil, polyethylene glycol.