Views: 0 Author: Site Editor Publish Time: 2021-03-15 Origin: Site
Tablet press for the requirements of drugs
The drugs for powder direct tablet should have a certain thickness or crystalline form; Drug powder should have good fluidity, compressibility and lubricity. But most drugs do not have these characteristics, which can be solved by improving the performance of drugs. For example, when the thickness and crystalline morphology of the drug are not suitable for direct tablet pressing, it can be improved by appropriate means, such as changing the particle size and distribution, changing the morphology, etc., such as recrystallization method, spray drying method, etc., but there are many difficulties in actual production and it is seldom used.
Low-dose drugs (such as the main drug content in 50 mg or less), the prescription contains more excipients, its mobility, compressibility, lubricity mainly depends on the performance of excipients. No matter the fluidity and compressibility of the drug itself is good or bad, it can be directly pressed after mixing with a large number of fluidity and compressibility excipients. Therefore, the premise of the powder direct pressing sheet is that the auxiliary material should have good fluidity, compressibility and lubricity.