Views:0 Author:Site Editor Publish Time: 2020-10-20 Origin:Site
The problems and methods of the tablet press
The disintegration delay in the tablet pressing process may occur in the tablet pressing machine, which means the disintegration time exceeds the pharmacopoeia.
Reasons for disintegrating delay: insufficient amount of disintegrating agent; high viscosity of adhesive; high amount of hydrophobic lubricant; high pressure; high hardness of tablet.
Solution: choose good disintegrating agent, or increase the dosage, reduce the adhesive dosage, or replace the adhesive with small viscosity, add hydrophilic lubricant, adjust the pressure of the tablet press.
Reasons for the big difference in weight: particle size, flow rate, not flexible down and rise, too much or too little charge.
Solution: re-granulation, add flow AIDS, stop check, adjust the hopper to make the same amount of packing.
Discoloration or spot refers to the change of hydrochloric acid on the surface of the tablet or the appearance of different color spots, pitting.
The reason is that the particles are too hard, the mixture is uneven, and there are stains on the machine.
Refers to the surface of the tablet of hydrochloric acid change or the appearance of different color spots, pitting, shadows
Solution: Re-granulate, mix well and scrub the machine.
Causes of unqualified uniformity and degree: uneven mixing, more fine powder, uneven particle size, poor fluidity, migration of soluble components.
Solution: Re-granulate, mix well, and improve the drying process.