Maintenance of single stamping machine 1, all moving parts on the surface of the friction lubrication is to ensure that the machine run properly and prolong the service life of the important link, especially if the main moving parts under the condition of lack of oil dry transit transfer quickly damage and cannot be used, so the tablet machine before use must be full cup of oil, oil hole, and the friction surface and lubricating oil, and empty operation make the friction surface is full of oil film, and then can be put into use. From now on, each shift refueling on time, but each refueling should not be too much, so as not to spill the influence of cleaning, stained tablets. 2, before each shift must check whether the screws are loose, in the process of work should also pay attention to check, if there is loose tighten immediately, so as to avoid failure. The main parts are: the upper punch fastening nut, the middle die fixing screw, the lower punch fixing screw; Connecting rod l

Tablet press filling instability how to do? Instability of filling will lead to tablet difference. Tablet difference means that the weight of tablet exceeds the allowable range of tablet weight difference prescribed by the pharmacopoeia. The causes and solutions are: (1) the particle fluidity is not good, the amount of particles flowing into the die hole is more or less, resulting in a large difference in sheet weight, should be re-granulated or added better flow aid such as micro powder silica gel, etc., to improve the particle fluidity; (2) too much fine powder or particle size difference, resulting in the flow into the mold hole when the material is heavy and light, should remove too much fine powder or re granulation; (3) the particles in the hopper are more or less, and the weight fluctuation caused by the feeding will also cause the sheet weight difference to exceed the limit, so there should always be more than 1/3 of the particles in the hopper; (4) punch and die

The raw material of the capsule Capsule shell hollow capsule by pharmaceutical gelatin and auxiliary material refined. Capsule shell is made of edible grade pharmaceutical gelatin after fine processing and auxiliary materials for holding solid powder, particles of the egg - shaped hollow shell. Capsule shell has good bioavailability and can dissolve quickly, reliably and safely. Gelatin is widely used in many foods, such as puddings, sweets, preserves, chewable candies, icing, food fillings, and dips. Gelatin is a popular, nutrient-rich and low-fat food ingredient that helps set, thicken, stabilize, and aerate food. Gelatin itself is a water-soluble protein extracted from collagen, the main naturally occurring protein component of connective tissue. Gelatin is obtained from the skin and bones of animals through a controlled extraction process. There are many types of gelatin. Capsules are made from pharmaceutical grade gelatin that meets stringent requirements for use in ph

Causes and treatment of explosive punch of tablet press The causes and treatment of detonation are as follows: Punch burst and missing Angle, metal chips may be embedded in the tablet. Due to improper heat treatment of the punch, it has damage and cracks without careful examination, can not withstand pressure or too much pressure of the tablet press, and can cause explosive impact when pressing crystalline drugs. The heat treatment method of punch should be improved, the quality of punching die should be checked, the pressure should be adjusted, and the appearance of tablet should be checked. If a detonation is found, the debris should be searched immediately and the cause identified to overcome it. The causes and treatment of the fault thrust are as follows: Fracture of punch or punch neck. Due to improper heat treatment of the die, there are damage cracks in the die without careful inspection, the pressure of the press or the tablet press is too large, and the fatigue lim

Type of die for tablet press There are many kinds of die, but we can distinguish them according to the different equipment, materials, standards and shapes used 1.1 According to the different equipment used, there are single punching die, rotary punching die, flower basket punching die and press punching die; 1.2 according to the different materials made, there are alloy steel die, carbide die, ceramic die, chromium plating, titanium plating die; The most common alloy steel materials for domestic die are: GCr15, CrL2MoV, CrWUMN, 9Mn2V, 9CrSi; The most common materials for imported die are: A2, O1, S1, S7, PHG.S, PHG-P. 1.3 According to different standards, there are ZP standard (GB12253.90) die, IPT international standard die, EU standard die and various non-standard special tablet press die and battery ring die; (High speed tablet press die standard JB/T20080.1-2006 (T series recently passed the joint examination) single stamping die tablet press because of its standard an

The die mounting method of high speed tablet press Before the die device, first remove the hopper, powder feeder, feeder frame and other parts, and the working face of the rotary table, die hole and the installed die piece by piece to wipe clean, get ready for the work, according to the following steps for installation. (1) in the mold device: the rotary table in the mold fixation screw out of the outer circle area and flat, do not make the mold loaded and the head of the screw touch, in the mold device is very tight, placed flat, can be used in the mold hitting rod (random tools) is punched into, used for hammer gently into the mold, the mold into the mold. The surface of the hole should not be higher than the surface of the turntable, which is qualified, and then the screw is fixed. (2) on the punching device: the upper guide plate should be pulled on the gap tongue, the end of the middle rod coated with some vegetable oil, inserted into the hole one by one, with the thumb a

Material preparation of capsule filling machine If pure drugs are crushed to the appropriate particle size can meet the requirements of plastic filler, can be filled directly, but most drugs in poor mobility and other reasons, need to add certain diluents, lubricants and other accessories to meet the requirements of filling (or clinical medication). Generally, sucrose, lactose, microcrystalline cellulose, modified starch, silica, magnesium stearate, talcum powder, HPC and other additives can be added to improve boring fluidity or avoid delamination. It can also be filled after adding auxiliary materials to make particles. Selection and sets, sealing glue of winnowing specification: should choose according to drug filling quantity of the specifications of the empty capsule, first of all, according to the provisions of the drug doses of volume to select the minimum empty capsules, can be determined according to the experience after the fitting, but the commonly used method is that the

Automatic operation of tablet press (1) Check whether the tablet press machine source meets the requirements of working conditions, and whether the upper and lower compressors are wiped clean. The high pressure of the tablet press is adjusted to the high pressure required by the tablet press, and the delay time under the high pressure is set (generally 5 seconds). (2) Under the premise that the power supply meets the requirements of the working conditions, the upper and lower indenters are wiped clean, the high pressure debugging is good, and the delay time is set well, the sampling spoon is used to take an appropriate amount of the grinded sample into the tablet box, and the tablet box is accurately placed in the central position between the upper and lower indenters. (3) Open the main power supply and motor power supply, press the start switch, the indicator light of the start switch is on, the lower pressure head starts to automatically rise to the contact sample, start to

Tablet press pressure size difference 1. the speed of the tablet, the speed is slow, the time of the pressure can be longer, and the hardness can be better. 2. The relationship between the pressure and hardness of the tablet press is proportional to the range of pressure changes; 3. The pressure of the tablet press has a great relationship with the hardness of the tablet, there is a zero point, when the pressure is very high, the film is likely to sliver, so it is not a constant pressure can be pressed into the film. In addition, the optimization of tablet pressing: 1) Adding microcrystalline cellulose with good compressibility is beneficial to the hardness of tablets 2) if the particles are too wet, after adsorption with silica gel, then pressure, hardness will soon come up 3) Sodium carboxymethyl cellulose can increase the hardness, different viscosity, you can try the CMC difference of different viscosity

What should be paid attention to before the capsule filling machine is used? 1, this equipment is a vibration machinery, should often check the fastening of all parts of the screw, if loose, should be tightened in time, to prevent failure and damage. 2, plexiglass parts (working table plate, medicine plate) should avoid direct sunlight and close to high temperature, can not use heavy objects, medicine plate must be placed vertically or flat, so as to avoid deformation and damage. 3. After finishing the work every day, the residual drugs in the machine and the mold hole should be cleaned to keep the machine clean and sanitary, and avoid flushing the main machine with water. If the mould needs to be cleaned on the machine, the fixing screw can be loosened to take it off. It is easy to install. 4, lock the reducer in the machine, the first time in the cumulative use of 24 hours to change the oil, the second time in the cumulative use of 72 hours to change the oil. After that,