Method of preparation of tablets Tablets are the most widely used dosage form at present. The production methods of tablets can be generally divided into dry preparation and wet preparation. At present, the wet preparation is the most widely used in China. However, because the dry preparation method is beneficial to the preparation of wet and heat unstable drug tablets, and has the advantages of shorting the process, reducing the amount of excipients and saving energy, especially with the development of new excipients and dry preparation equipment, the application of dry preparation method has been paid more and more attention and adopted by pharmaceutical enterprises. Dry preparation includes dry granulation method and direct compression method. Dry granulation and tablet pressing method is to mix the drugs and auxiliary materials into large pieces with appropriate equipment, and then break them into appropriate size particles, or directly squeeze the raw materials into particle

Preparation method of tablets The preparation methods of tablets include wet granulated tablets, dry granulated tablets, powder direct tablets and freeze-dried tablets, etc. Direct powder tablet means that the powder is directly pressed into tablets, separately screened, mixed with appropriate excipients, without wet granulation or dry granulation direct tablet. Because the technological process is simple, no need to granulation and drying, save energy and time, protect the stability of drugs, improve the solubility of drugs, achieve a high degree of industrial automation, more and more domestic pharmaceutical companies used. Data show that about 40 percent of overseas tablet varieties are produced through a single process. Compared with traditional wet granulation, the most obvious advantage of direct crushing technology is economy. In traditional wet granulation, the amount of adhesive, the drying time of the granule and the screening time of the alcohol granule must be conside

Adjuvants in tablets The most commonly used adjuvants in tablet preparation are fillers, thinners, adhesives, lubricants and disintegrants. Diluents and adsorbents, collectively known as fillers, are used to increase the weight and volume of a tablet. If the drug itself is sticky, particles can only be made by adding a wetting agent. The most common fillers or thinners are starch, powdered sugar, dextrin, cream, compressible starch, microcrystalline cellulose, and inorganic salts. Some powder itself is not viscous or low viscosity, need to add a sticky substance, such as starch paste, to bond together. Commonly used adhesives: ethanol, starch pulp, sodium carboxymethyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose; In addition to oral, sublingual, palliative, and controlled-release tablets, a disintegrating agent is often required. These tablets need to be dissolved and released slowly. Common disintegrating agent: dry starch, carboxymethyl starch so

Classification of tablets Ordinary tablet: A tablet mixed with an excipient, usually taken with water. Capsule: A piece used to line the cardiac membrane. The purpose of coating is to improve the stability of the drug in the tablet, cover up the odor of the drug, improve the appearance of the tablet and so on. Sugar-coated tablets refer to tablets made from sugar-coated materials. The coated film refers to the flake of subcontracted polymer film; Enteric-coated tablets refer to the insoluble gastric juice which is outsourced, but the soluble long-leaf tablets are used to prevent gastric juice damage and gastric irritation. Multilayer tablet: Tablet consisting of two or more layers (different ingredients, formulations, or colors) to improve appearance or regulate duration of action, or to reduce exposure to two layers of medication, or to reduce changes in compatibility, etc. Tablets may be divided into two or more layers from top to bottom, or several layers, concentr