Characteristics of capsules A capsule is a preparation containing a drug in the form of a capsule by dose. Gelatin is usually the main material of capsule, sometimes to change its solubility or to achieve intestinal solubility, etc., there are also methyl cellulose, calcium alginate, modified gelatin, PVA and other polymer materials. The capsules mask the drug's unpleasant smell and are easy to swallow. To improve the stability and bioavailability of drugs; It also regulates and localizes drug release and can compensate for other widely used solid formulations. No drug should be made into a capsule because it is soluble in bagged material, wears away easily, and is very irritating. Characteristics of capsule: 1. It can mask the odor of a drug or improve its stability. To be isolated from the outside world, to avoid the influence of moisture, air and light, and to have a certain degree of shielding, protection and stability for odorous or unstable drugs; 2. Improve the bioav

Development of blister packaging materials for adhesives At present, aluminum foil coating adhesive is mainly composed of one - component and two - component adhesive. Glue is mainly composed of natural glue or synthetic glue and acrylic acid composition, because it is mainly elastomer, plus viscosity additives and organic solvents mixed with emulsion, with strong thermal solubility, strong adhesion and other characteristics. As health requirements increase for pharmaceutical packaging materials, the use of newly produced single-component adhesives is gradually decreasing, and mainly two-component polyurethane coatings. The main mechanism of the adhesives is the master agent and the fixative agent, which usually contain many active hydrogens, such as hydroxyl, amino hydrogen and other substances solidified composite isocyanate vinegar. The addition reaction occurs automatically when it comes into contact with the active hydrogen of the main molecule of the chemical reagent, formi

Check the work of the tablet press Rotary tablet press adopts the principle of mechanical tablet press to form different powder tablets. Tablet pressing machine is divided into 5, 7, 9, 15, 17, 19, 29, 31, 33, 35, 37, 41 and other different specifications of the tablet pressing machine, suitable for different ways, such as wafer, pharmaceutical factories, chemical plants, daily chemical laboratory, etc. (according to the needs of customers for various types of tablet pressing). The whole machine is made of stainless steel, the motor adopts national standard and conforms to GMP hygienic standard. The exterior facade is made of plexiglass, which effectively prevents cross contamination of dust and makes the working environment clearer. This machine is a fully automatic tablet press. The thickness, pressure and speed of the press can be adjusted according to the actual needs to realize the real mechatronics, using touch buttons and display screen to display speed, production, failure,

Do you understand the new functions of the tablet press? Foreign tablet presses the speed, the yield is high. High speed and high yield have been the goals of tablet forming for many years. The main plate-forming machinery already has machines that produce one million pieces per hour. If the domestic production of the tablet press, if the production speed of China's tablet press is faster than that of foreign countries, the need for large-scale tablet press innovative design and development, information processing, automatic control and other processes. Sealing of stamping process and isolation of personnel flow and logistics. The input and output of foreign presser are well sealed to minimize cross contamination. Particles enter the hopper through a closed drum and a closed transport system. Effective measures should be taken to prevent dust spatter and particle stratification during the pressing process. Most of the domestic pressing process is open or not completely closed, th

Blister packaging for material control For blister packaging aluminum foil is the main material to cover the opening, is also a good barrier packaging material, pinhole in penetration is a fatal defect. During the packaging, transportation and storage process, extrusion, collision is inevitable, so the size of the pinhole or the range of aluminum material or increase, which may cause the material to have obvious fracture marks, which may lead to deterioration in the properties of aluminum material it speeds up the infiltration of gas and water vapor, affecting the stability of the aluminum material. In general, there are two methods to accurately assess changes in pinhole conditions and changes in covering materials. First of all, it is suitable for the kneading behavior that may occur during the circulation of packaging materials through the kneading test device. Secondly, the strength of coating material before and after friction is tested, and the change of data directly refle

What do you know about the small problems with the capsule filler? Questions about semi-automatic capsule filling machine: What if there were individual capsule shells with openings facing down? A: You can put the capsule under the lid and gently press the lid to cover it. What if you accidentally pour a lot of powder? A: Excess powder can be scraped off with a random powder board. 3. The capsule cannot be taken out after being encased. What should I do? A: Gently press down with your hand. Note: 1. The device is a vibration motor, and the screw fixation of each component should be checked frequently. If it is loose, it should be tightened in time to avoid damage. 2. Plexiglass components (work table, cover plate) should avoid direct sunlight in high temperature, and heavy objects should not be piled up. Cover plate should be placed vertically or flat to avoid deformation and damage. 3. The electrical housing and fuselage shall be connected to the groun

Advantages and development of blister packaging Machine The excellent barrier performance of blister packaging is due to its choice of raw materials, aluminum foil and plastic hard sheets. The aluminum alloy housing adopts high density metal crystal structure, which has good barrier property and light resistance. Blister packaging has the advantage of being easy to carry over compared with bottled medicine, reducing the contamination caused by the product during transportation and use. In addition, blister packaging has obvious advantages in gas, barrier, moisture penetration, health and safety, high production efficiency, accurate dose, and prolongs the service life of the product. Another advantage of blister packaging is the automatic packaging process, which ensures the safety of drug packaging. The automatic blister packaging machine includes blister forming, drug filling, sealing, folding, manual insertion, blister packaging, carton sealing and other processes, which are co

The purpose of granulating tablets At present, the production technology of pressing includes post-granulating and direct pressing. The production technology of granule tablets can be divided into wet tablets and dry tablets, and direct tablets can be divided into powder tablets and crystalline tablets. But now with wet grain preparation in the majority. Purpose of granulation: (1) The fluidity of fine powder does not flow evenly into the mold hole, which affects the accuracy of the tablet weight. When particles are formed, they can overcome the difficulty of being pressed into thin sheets due to a lack of fluidity. (2) A certain amount of air in the powder forms tablets under pressure. Part of the air in the powder can not escape in time, is pressed into thin tablets; When decompressed, the air inside the tablet expands, causing it to crack. At the same time, the powder in the press pressure is very high, will cause mechanical damage. The pressure after granulation is less

Check after capsule filling Take the capsule of 10 products, gently pinch the two ends of the capsule with thumb and forefinger, rotate the capsule away without any bond, deformation or rupture, and then put talc powder into it. The cap and the capsule are closed, one after the other, and drop vertically on the 2cm thick plate at a height of 1 meter, and the powder should not leak. A small amount of powder shall not exceed 2 particles. If this limit is exceeded, an additional 10 capsules should be collected for new testing, all of which should meet the requirements. A plate of 50 capsules on vessel, into the dry container containing magnesium nitrate solution, to a constant temperature for 24 hours, remove and immediately, respectively, the vertical grain on the wood grain (2 cm) of glass tube, the weight of the cylindrical weight (ptfe material, 22 mm in diameter, about 20 g weight) from the glass tube mouth free fall, whether capsule rupture, such as fracture should not exceed

Stamping die installation for sheet pressing machine Before installing the presser, clean the surface of the turntable, the upper and lower punching rod holes, the middle die rod holes and the press die to be installed, and then install according to the following procedure. Open the plexiglass front door. To install the middle die: first, the fastening screw fixed on the rotary die is unscrewed bit by bit, so that the head of the screw is shrunk to the outside of the middle die hole, so that the middle die can be plugged into the middle die hole in the form. Then press the middle mold into the middle mold hole with a special middle mold handle until the middle mold goes under the middle mold hole and then tighten the middle mold retaining screw. To install the up-punch rod: turn up the upper guide rail tongue and insert the hole of the up-punch rod. (Please note that the punch shall be able to rise, fall and rotate freely within the punch hole without any hindrance).