Why are tablets made before pressing? Both granulation and tablet compression are designed to avoid direct contact with the stomach and intestines to reduce the effects of drugs. Solid drugs dissolve in the body before they are absorbed. Why do you need to pelletize before pressing？ Granulation is an important means to ensure the quality of drugs. Make sure there are no cracks or looseness. What is the technological process of wet tablet pelletizing? Raw materials and accessories, grinding, sieving, mixing, making soft materials, granulating, drying, whole granulating, total mixing, pressing, coating, packaging, finished products. Wet mixing time for preparation of Chinese medicine tablets: Samples were collected during premix, i.e. wet granulation, and their RSD values were analyzed. Then, after complete mixing, it is necessary to test the sample content and calculate the RSD value, because complete mixing is the final mixture, which directly affects the subsequen

What if the blister packing machine runs out of sync? Running out of sync, the bubble cap to be formed cannot enter the hot die hole precisely: The forming and sealing of the hot seal die are not integral multiples of the stroke; Poor cooling of the forming mould and the hot sealing mould, and there is a plug between the forming mould and the hot sealing mould; The hot seal mold temperature is too high to rotate the plastic support shaft. Adjust the lifting shaft and add oil to the shaft. The cooling water quantity increases moderately; By observing the distance between the feeder and the plate surface, check whether the hot seal channel of the feed is blocked; Cleaning or replacement of bearings; Adjust to reduce the heat seal temperature. Aluminum foil is not well combined with PVC plastic (not parallel); The rotating rod of the aluminum foil is not perpendicular to the vertical line of the PVC plastic sheet; The net grain rusts, there is dirt; The adjustment of the rolle

How does the tablet press operate? Operators should first read the operating rules and operating instructions of the press, familiar with the performance of the press and the use of control parts. Stamping die should be checked strictly before normal use. Cracks, missing edges or deformation are not allowed. The installation should be properly tightened. Do not use if unqualified. The particle size of raw materials is an important factor for the success of pressed tablets. The pressing quality must be controlled according to the process requirements, otherwise it will affect the pressing quality and the normal operation of the machine. The speed of the tablet has an effect on the quality of the tablet and the life of the device. In general, for materials that are difficult to form, it is slower to choose tablets with large diameters and faster to choose tablets with small diameters. When no load, the volume of packing should be increased to prevent the upper and lower pu

What is the excipient classification of press tablets? What are the auxiliary materials of tablet pressing machine? How do you classify them? 1. Fillers: also known as diluents, mainly used to increase the weight and volume of tablets. Common fillers contain dextrin and starch. When the main drug in the filler is oil or liquid, the filler is added to absorb liquid, which is called absorbent filler. 2. Resolver: The tablet is quickly and effectively decomposed into the gastrointestinal tract immediately after ingestion, so that it can be dissolved and absorbed and play its curative effect quickly. Decomposition agents are hydrophilic objects, with good adsorption and expansion ability, commonly used starch and carboxymethyl starch. 3. Wetting agents or adhesives: After some drugs or auxiliary materials are wetted, they have enough viscosity to produce sufficient viscosity by adding appropriate liquid called wetting agent. If the drug is less sticky or less sticky on its own. When so

How does pressing machine appear top car situation? Handling after loading If jacking occurs when the tablet press is pressed, the power should be turned off immediately to prevent engine combustion. When the loading condition is relatively light, the upper thrust force can be passed through neutral by hand wheel, but not reversed, to avoid repeated feeding by feeder, which will cause more serious situation. When the jacking is serious, loosen the lock nut, turn the impact lever to raise it to reduce pressure, and turn the handwheel to push the pill out. Then adjust the hardness of the tablet. In the press process, often check the quality of the press (weight, hardness, surface finish, etc.), timely adjustment. The mixing granulation process before pressing has great influence on the pressing process. For example, the formulation of the material (powder state, particle size, powder particle ratio, water content, etc.) directly affects the weight of the tablet. And oft

How to press the tablet hardness is not enough? Generally, tablets produced by the tablet press will have insufficient hardness, but this does not necessarily mean that the pressure of the tablet press is not enough, and there are some other factors: Factor 1: The amount of adhesive or lubricant is low or insufficient, resulting in uneven distribution of particles and stratification of coarse and fine particles. Even if the pressure increases, insufficient hardness of the tablet cannot be solved. Solution: choose the right adhesive or increase the dosage, improve the granulation process, mixing particles evenly, etc. Factor 2: Insufficient fineness of drug crushing, high fiber, elastomer or oil content, uneven mixture. Solution: can crush the finer drugs, adhesive can be selected, increase the tablet pressure, completely mix oil absorbent, etc. Factor 3: In the drying process, in the case of insufficient moisture, too little dry particles or too elastic, drugs contain

The spherical mould for the tablet press Our general production of powder press machine and mold. Our powder press has small size, high pressure and high pressure control precision. Widely used in scientific research, teaching, testing, pharmaceutical, catalysis, chemical and other fields. In addition, the product can be used together with Fourier infrared spectrometer, fluorescence spectrometer and other detection instruments for sample preparation, and can replace similar imported products. Ordinary rectangular mold is suitable for cement, ceramics, powder metallurgy, infrared, fluorescence, calcium iron, building materials, superconductors, batteries and other new materials. Spherical molds are used in the pharmaceutical industry and for small batch testing. Special mold sizes can be made according to customer requirements: 1. Assemble the mold according to the working principle of the mold and send the sample into the mold cavity; 2. Put the mold in the center of the ta

How to operate a high speed tablet press? 1. Before use, repeatedly check whether there are edges, cracks, deformation, insufficient compaction and other conditions of the press die quality, and check whether the equipment is complete and whether the work is normal. 2. Check whether the dust in the granule raw materials is dry. The dust content in the granule should not exceed one tenth. If not meet the requirements, please do not press hard, otherwise it will affect the normal operation and service life of the machine, and cause the loss of raw materials. 3. The first command control of the pressure regulator, the powder into the bucket, turn the test by hand wheel, regulating drug packing at the same time, gradually increase the pressure gain weight into need to finished product, and then start the engine, open the clutch and the formal operation, the production process should be regularly checking the quality of the drug, if not qualified, adjustment, normal operation if qu

How to use automatic capsule filling machine? Before using the automatic capsule filling machine, please check whether all parts of the machine and equipment are in good condition, and disinfect and clean the instrument as required. According to the filling volume and other process requirements, select the appropriate tray, powder or particle filling system specifications. 1. The support is placed parallel to the material plate, and the filling rod is perpendicular to the support, so as to ensure that the filling rod can easily enter the filling hole of the material plate. Loosen the fixing screw and lock nut, rotate the screw to the desired height, calibration lever has scale, then tighten the screw and nut, fill seat height adjustment is finished. 2. After all the safety configurations have been configured and adjusted, the machine should be rotated 1-3 times in the absence of capsules and drugs to turn the machine to the working direction and turn it back with the hand whee

How to deal with poor heat dissipation of blister packing machine? Generally, poor heat dissipation of blister packaging machines should be inspected for chiller devices. Generally, the treatment method for poor heat dissipation of blister packaging machines is as follows: Cooling condenser, compressor, low operation efficiency, and high voltage current rise, when the high pressure air cooled to 24 kg/cm2, water cooling of the cooling air pressure for 20 kg/cm2, reconstruction of high-pressure compressor high pressure protection switch, closed compressor, high pressure thermal overload fault indicator and shows fault code, please check if the water tower is normal, if the cooling water temperature rise, cooling fan and cooling pump valve door open operation, please check whether the radiator is air cooled dirty or plugged, more than normal, then press the reset button or turn it off to rest after the restart. If high voltage overloads often occur, clean the capacitor as soon as p