The pressing machine needs to be improved In recent years, tablet press manufacturers generally pursue high speed, high yield and low cost in product design and manufacturing, and pay less attention to the modern management and GMP requirements of pharmaceutical companies. Due to the limitations and defects of the equipment, the tablet press used by most small and medium-sized pharmaceutical enterprises has brought many practical problems to GMP management and product quality. For example, contamination, difficulty in cleaning, inability to test products online, manual filling of equipment operation records, etc. One of the main reasons for the pollution of the tablet press is the improper design of the lubrication system, which has not fully considered the particularity of the pharmaceutical equipment. Equipment manufacturers may consider adding regular grease lubricants to the tablet press or adopting a reliable seal to reduce or eliminate lubricant contamination of the drug. Ano

Test the tightness of blister pack The sealability test and leakproofness test of the drug package should be carried out in the process control. The tools used to test a package leak analyzer are commonly called package integrity testers, and tests for leakage and sealing strength should comply with ISO standards and medical equipment packaging standards for periodic disinfection. Packaging test systems shall include testing of packaging integrity and tightness in accordance with this standard. For non-porous packaging, packaging integrity and sealing strength tests can be carried out; However, for packages that are permeable or porous, the test applies only to tests of seal strength. For medical equipment, aseptic packaging or flexible food packaging, necessary tests are required to ensure the safety of the product, for example, with regard to hose seals, cup and lid seals, or in pharmaceutical packaging and blister substrates. Seal strength test The strength of the seal d

Design of press die The three main factors that determine the quality of tablets are the raw material formulation, the tablet press and the press die. In recent years, the company produced a lot of press die matching, is still increasing, the three elements of the press die correct design and careful manufacturing is to ensure the machine high speed efficiency and production quality of the key part. The following is a summary of the techniques we should consider when designing, manufacturing and maintaining high speed die presses. (1) Die design of the press machine. Die design is not only to coordinate the selection and adjustment, for example, up and down punch and punch hole, die diameter and die hole, down punch and fill protection guide, punch and die hole, and so on, but also to make the forming sheet out smoothly. In addition, special attention should be paid to the die sheet design. For the pharmaceutical companies that make pills, the question is how pills promote chewin

The vacuuming device of the tablet press Rotary tablet press has become the main equipment for tablet production. Due to its high yield, stable quality and large production capacity, it has been widely used by pharmaceutical enterprises. According to GMP requirement, rotary tablet press should have vacuum device. The main working process of rotary tablet press is divided into three continuous processes: filling, pressing and extraction. During the production process, the powder is easy to fall on the middle punching plate due to the feeding device or the feeding itself. At the same time, it is usually equipped with external vacuum cleaners, mechanical precipitators, wet precipitators, electrostatic precipitators, filter purification precipitators, etc., but the common mechanical precipitators, whose main structure is to suck the vortex through the pump, the vortex pump impeller has dozens of blades. Spiral pump impeller rotating blade in mid-air is the effect of centrifugal induction

The production problem of domestic tablet press There is dust problem during the pressing process. The solution to the powder problem in the pressing process is discussed below. (1) Dust source analysis. At present, the dust produced by high-speed rotary machines and household screening machines in the production process is generally extracted through the negative pressure provided by special vacuum cleaners. However, due to the insufficient technical level and sensitivity at present, the sealing effect of the equipment itself is not good, and some dust still leaks into the purification zone. In addition, particles produced during the transport of substances or tablets may be released directly from the associated joints into the purified area. (2) Actual purification index. At present, domestic GMP purification level mainly focuses on static indicators. In this case, the powder produced during the stamping process is usually ignored. In Europe, the United States, Japan and oth

What are the causes of dust produced by the tablet press? 1. Dust is generated during the manual feeding process. 2. When the equipment is in normal operation, the process of upper punching: The dust generated is adsorbed by the plexiglass door, so the operator cannot see the pressing situation clearly. For normal production, the plexiglass door has to be opened, which is not in line with THE GMP standard. The uprush also gets into the dust. Powder adsorption lubricating oil due to the lack of oil and regular injection. If it is not cleaned in time, the up-rush and up-guide rail will often wear down, resulting in the equipment can not work normally. The dust generated by the equipment running for a long time will enter the electric control box and cause electrical faults. Dust will contaminate the stamping room, making it difficult to clean and disinfect. 3. During the operation of the equipment, dust in the stamping process is absorbed by powder suction nozzle, bu

What are the ways to reduce dust? Method to reduce dust during manual feeding: add a round cover on the hopper, and cover it timely after manual feeding to prevent dust diffusion. Vacuum feeder is used to seal the hopper to reduce dust production in stamping process. Method to reduce dust during upstroke operation: after the dust removal of the feeder, the dust inlet of single dust layer is reformed so that it can suck out the fine particles of the double dust chamber of the rotating work table of the pressure plate. An inlet cover affixed to the opening of the outlet groove top or connected to the inlet hole to prevent dust diffusion at the outlet and during the outlet process. Add a cover plate above the feeder. This method is not applicable to forced feeding. The feeding port of the hopper and the feeding port of the forced feeder are connected to seal the feeding port of the hopper to the inlet pipe of the forced feeder. The natural feeding grid feeding network is cover

Do you understand the development direction of blister packaging? Blister packaging machine for drugs is also known as PTP packaging technology, blister packaging technology has developed rapidly in recent years as a form of drug packaging. PTP technology is used to heat and soften the plastic film and place it in the mold, or to form the bubble shell by blowing compressed air through vacuum pump. Then, it is coated with plastic aluminum foil for medicinal use at a certain temperature to ensure that the bubble wrap package is formed under the sealing condition. At present, blister packaging has become the mainstream packaging for capsules, tablets and other solid dosage forms, and the development momentum will continue. Blister packaging in China the status of the drug and the deepening of China's reform and opening up and reform of medical system, especially after China's accession to the WTO, the international pharmaceutical companies to enter China, competition in the pharm

Development of single - stamping and multi - stamping machines Tablet press is suitable for laboratory experiment production or small batch production of various tablets, sugar tablets, calcium tablets, heteromorphic tablets. The machine for continuous pressing is equipped with one set of punching die, with adjustable filling depth and thickness. The high speed rotary tablet press has the characteristics of high productivity, high pressure, continuous prepressure adjustment, compact structure, simple operation and maintenance, reliable operation, wide range of material selection, low operation cost and good performance ratio. In addition, the machine has the advantages of small vibration, low noise, low energy consumption, high efficiency and accurate weight. When working, the machine should be rotated to a high position to observe whether the surface of the lower punch is flush with the middle die, or whether the surface of the lower punch is flush with the middle die. If not fl

Problems affecting the pressing and forming of the tablet press The special tablet press is another important factor in tablet forming. The performance of the tablet press, the mechanical operation of the equipment and the wear degree of the mold directly affect the quality of the tablet. According to the specifications and models, the pressure of the rotary pipepress is greater than that of the special pipepress for impacting profiles, the pressure is uniform, and the split phenomenon is easy to control. Due to the fixing of the cartridge, the machine vibration is small, the particle stratification is small, the tablet weight is accurate and stable. But this particular type of rotary tablet press also has several models of single-track and double-track. When there is a weight difference in the production of tablets, you should consider that your tablet press is a special type of machine with a double-track structure that makes the particle speed and compression time shorter than