Conditions for filling capsules Oil-based drugs and low melting point drugs are most suitable for the production of soft capsules. Oily drugs are all liquid or semi-solid at room temperature, which are pretreated at room temperature and commonly used in the preparation of adsorption, treatment and other processes. Auxiliary materials such as the addition of a large number of adsorbents, during the preparation process, the drugs that are easy to dry and heat become free or exudate, and the main drugs become ineffective, affecting the efficiency. And gelatin soft capsule is oily drug and low melting drug in the solution or filler or emulsion drops, general excipients are adsorbed, can not only preparation miniaturization, but also can avoid the product how to release and exudate. Such as vitriolic oil pills, vitriolic oil pills, anti-inflammatory drugs, etc. Sensitive to light, unstable at humidity and high temperatures, readily oxidizable drugs can be made into soft capsules. Some

Blister packaging technology for drugs Product blister packaging refers to the product filled with drugs, through vacuum (suction) bubble or compression molding blister, using aluminum foil, under a certain pressure, under a certain temperature and time conditions, together with the base material heat sealed and formed. Blister packaging, also known as drug blister packaging, is one of the main forms of drug packaging, suitable for tablets, capsules, suppositories, pills and other solid preparations of mechanical packaging. The rise of blister packaging in China was as early as the 1930s, when the bubble packaging of drugs first developed vigorously in Europe and was gradually promoted and used in the world. Later, China introduced medical blister machinery and equipment, but still needed to import foam packaging materials such as aluminum foil. Until the foreign advanced blister packaging material production of aluminum coating printing production, first introduced the National Med

Problems and solutions in the process of tablet pressing A tablet is prone to lobes during pressing: the tablet splits from the waist or top after being shaken or placed. The main causes of the split: elastic recovery of the tablet, uneven pressure distribution, too fast pressure, improper selection of adhesive or insufficient dosage, too much fine powder and die. Solution: change the small elastic accessories, reduce the speed of the tablet, adjust the uniform pressure, select the appropriate adhesive or increase the amount of die, replace the die. Loose sheet: the tablet is not hard enough, in the process of packaging and transportation The phenomenon, single stamping machine is more prone to occur The main reason of loose tablet: drug elastic recovery is big, can pressure is bad. Solution: select adhesive with strong adhesion, adjust the pressure of the tablet press. Adhesive punch: Fine powder is stuck to the punch or die, resulting in one-sided unevenness or

Application of extrusion particle technology The technology of extruded granules brings new ideas for the research and development of new drugs and traditional Chinese medicines. Mainly used in the following fields. The first is the secondary development and application of Chinese medicine. Some species of drugs need to be modified, because of the high leachate volume, single dose, can not choose capsules, tablets and other small dosage forms, but only granule, pill and other forms, even if the dosage is large, but not competitive in the market. Some genera take tablets in large quantities to improve the quality of the variety by improving the accuracy of taste identification or increasing the limit of sample content. If the extruding granulation is used for the secondary development of Traditional Chinese medicine preparations, the number of drugs or the capsule type can be reduced, and the capsule type of other drug products can be selected not only in the medicine mode, but

Type of packing Packaging design is based on the basic function, ease of use and reuse of packaging protection as well as the actual production conditions, on the basis of scientific principles, considering the internal and external structure and design of packaging. A good structural design with effective asset protection as its main function is followed by ease of use, ease of transport, exhibition, transport, etc., as well as the possibility of reuse, display content and other functions. Classification by product sales: packaging of domestic and export products; According to the role of packaging in the cycle: single packaging, intermediate packaging, outer packaging; Packaging materials: paper products packaging, plastic products packaging, metal packaging, bamboo packaging, glass container packaging, composite packaging; Packing according to usage frequency: single packing, multiple packing, revolving packing, etc. According to the hardness and hardness of the

Powder crush candy Direct powder pressing is a process in which the main components of powder are screened separately and mixed with appropriate excipients without granulation. The direct powder pressing process requires only a few steps and does not require granulation, compaction or drying, which simplifies the production process, improves production efficiency and saves energy. It is especially suitable for main components that are easy to change color and decompose under hot and humid conditions. With the modernization of tablet pressing equipment and the rapid development of high-quality auxiliary materials, the direct powder stamping process has accounted for more than 40% of the tablet production process. Tablet fructose is a new type of confectionery, which belongs to confectionery. With the acceleration of the pace of modern life and the enhancement of people's health awareness, flake candy products containing natural plant or dried mushroom powder, natural plant or ed

Development of capsules The preparation process of Traditional Chinese medicine is divided into two parts: extraction process and molding process. In order to solve the common problems in the production of traditional Chinese medicine capsule preparations, some Chinese scholars put forward the concept of "granulated capsule" (such as biscuit). Assuming that the total volume capsule is M V and the prepared daily dose is according to the formula M = P V, we know that with M, it is necessary to reduce the particle heap density required by the increase of V, that is to say, reducing the number of particles significantly increases the particle density. If the prepared particles have small specific surface area, smooth and round appearance, dense texture, not only waterproof, but also easy to package. Membrane coating can not only improve the moisture resistance of particles more effectively, but also change the external color of particles through the packaging of special materials t

Advantages of blister packaging products It is a packaging method that seals the product between the blister layer and the bottom plate of the transparent plastic film, which is composed of the base material, cardboard, film or plastic film, aluminum foil or its composite material. Typical process flow: plate heating, film forming, item filling, substrate substrate, heat sealing, cutting and trimming. Material: plastic board, base material, coating material. Blister packaging is a unique packaging, blister packaging is easy to have automated assembly line or production, but the need to replace the mold, suitable for mass production of fewer packaging varieties, blister packaging beautiful, can improve the value of goods. Blister packaging is used to prevent moisture absorption and invalidation of the items in the package to ensure that the quality of the items is stable, that is to say, the packaging material has a good barrier performance to prevent the increase of water or the loss

The advantages of tablets and capsules The advantages of tablets and capsules. First of all, these are two different forms, the concept of a drug. Drugs can come in many forms, such as amoxicillin tablets and amoxicillin capsules. Although the main drugs are the same, the dosage forms vary greatly. Tablet is a solid preparation made of pressed excipients. After they are taken orally, they take some time to break down by absorbing water from the body. A capsule is a drug made from hydrolyzed animal bones and hides. Fast absorption and high bioavailability after oral administration. But high temperatures and humidity can nullify the changes in the capsules. The importance of drug forms 1. Drug forms can alter the rate of action of a drug: for example, injections and aerosols may act faster than capsules, tablets or pills. 2. The dosage forms may alter the nature of the drug's action: for example, magnesium sulfate may be taken orally as a laxative, while injectable dosage

The production technology of Traditional Chinese medicine capsule Generally speaking, there are some common problems in Chinese herbal medicine capsules, such as limited quantity of medicine, hygroscopic of filling material, and irregular granules. Taking traditional Chinese medicine capsule usually too much capsule, especially some compound capsules containing more supplements. The overdosage of capsule tablets is mainly related to the high solid yield of raw materials, the large amount of excipients and the defects of various traditional Chinese medicine granulation methods. The yield of solid is too high, and the technical means and methods that are often used at present, such as static precipitation, precipitation method, alcohol and water filtration technology and method clarification and high-speed centrifugal filtration method, can reduce impurities, extract relevant raw materials and reduce the amount of leaching. However, from the perspective of extraction technolo