Blister packaging material characteristics PTP plastic board is the most commonly used PVC board. Although PVC has a lot of advantages, such as good quality, low price, but in the moisture-proof, mildew-proof, water-proof, anti-oxidation and other aspects are not very good. In addition, the production or use of PVC has a long-term impact on both the environment and biology. In the preparation of PVC plastics, the main problem is the polymerization of vinyl chloride monomer, such as vinyl chloride monomer additive, plasticizer, stabilizer and so on. PVC incineration process products such as dioxins hydrochloride. Hydrochloric acid produced after PVC decomposition has a certain impact on the environment, and its monomer, plasticizer and stabilizer are harmful to human body. At present, foreign developed countries began to ban and restrict the use of PVC bubble packaging, the need for new packaging plastic bubble must be synonym, oxygen and water, good performance to ensure the effective

The filling method of the capsule Add appropriate auxiliary materials such as diluents, flow AIDS and disintegrating agents to make drugs into even powder, particles and tablets. Fill ordinary powder, pill and tablet separately or after mixing. If necessary, add an appropriate amount of empty pills as filling agent. If it is a small dose of medicine filling, can be diluted with an appropriate amount of diluent, and then evenly mixed after filling, capsule should be clean and beautiful, no bond, deformation, rupture or odor. The dissolution, release, content uniformity of the capsule should meet the requirements, pay attention to the contents of the capsule coated to check the residue. Capsule should be sealed preservation, temperature and humidity appropriate, in order to prevent mold, moisture, metamorphosis, the finished product should be quality testing, qualified after the selection of sealed clean container packaging, generally with aluminum blister packaging for the majority.

Tablet content and hardness Compressed content uniformity consistency inappropriate generally occur in the micro pill tablet and small doses of the drug tablet, medicine or percentage of the main: micro pill particles, particles due to the thickness size is different, the same materials and layered materials completely mixed granulation process, machine vibration, the better solution is to decrease the rate of tablet (affect the method of production efficiency, but is there a better way to be determined). The components of low-dose tablets vary greatly, so it is difficult to mix them in one stage. Due to the change of prescription, they can be used to increase or disperse the solvent in the same amount. For example, the liquid system granules are mainly added, while the mixing time of hydrophobicity is prolonged. Soluble component migration is completed, granulation and drying the coating or coating process steps, drying in the evaporation process brought some soluble components

Development of blister packaging In addition to all kinds of bottle packaging, blister packaging can be considered as the most commonly used packaging. Blister packaging has many advantages, it can provide patients with a single dose of drug packaging, convenient and economical. In addition, aluminum-plastic blister packaging protects the performance of the drug, which is fast in production, low in cost, small in storage space, light in weight, convenient in transportation, safe and reliable. Because blister packaging has instructions printed on the surface, incorrect distribution of several tablets can be avoided. Therefore, blister packaging will become the main way of tablet and capsule packaging. The following is a brief introduction to the characteristics of pharmaceutical blister packaging and the problems that should be paid attention to in the printing coating. Blister packaging is the most commonly used ideal packaging method in drug packaging. By aluminum foil, formi

Characteristics of hard capsules After hard capsule filling, the surface often contains a small amount of drugs or excipient powder, which needs to be cleaned. It can be lightly rubbed with gauze coated with a small amount of liquid paraffin to make it glow, and then packaged in an aluminum-plastic packaging machine or in a suitable container. The capsule has a clean and beautiful appearance, which can cover the bitter taste and unpleasant smell of raw materials, making it easy for consumers to accept; Functional factors have high bioavailability and low excipient content. In the preparation process, no paste can be added, no pressure, so it can be dissolved quickly. In the gastrointestinal tract, the breakdown and release of food substances normally occur 5 to 10 minutes after administration. Compared with pills and tablets, the capsule has obvious effect, fast absorption and easy absorption. Very stable. For example, vitamins should be placed in opaque hard capsules to promote

A minor problem in the press process In the press process, often face a variety of small problems, such as particles are too dry, lack of water, or because of excessive moisture air, or due to the press machine is not normal, such as heavy head and mold grinding damage, resulting in adhesion and spots on the surface, excess weight difference, lamination, hemp, etc. These details often affect the quality level of the product. Lamination refers to the pressing of two sheets together, the reasons for lamination and the corresponding measures: When pressing, the edge of the pressing piece is pasted or the upper pressing piece is rolled, and then the pressing piece is compressed into the filled forming hole to form a double pressing piece; Or because the falling and rising positions are too low to send out the particles in time, the particles are added to the die hole under repeated pressure to form a thick sheet. As a result, the pressure is high and the machine is easily damaged. The

Control of blister packaging materials Aluminum foil is the main material to cover the opening, is also a good barrier packaging material, pinhole is a fatal flaw in penetration. May occur during the process of packing, transporting and storing filler extrusion, extrusion is inevitable, so the increase of the diameter of the aluminum foil pinhole or range, which may lead to obvious crease, this can lead to a breakthrough in the aluminum material properties, it accelerated the gases and water vapor permeability, influence on the performance of the stability of aluminium material cut off. In general, there are two methods for accurately assessing changes in pinhole conditions and covering material barriers. First of all, it is suitable for the kneading behavior that may occur during the circulation of packaging materials through the kneading test device. Secondly, the strength of coating material before and after friction is tested, and the change of data directly reflects the chan

Preparation of capsule filling materials If the pure product is pressed to the appropriate particle size to meet the requirements of capsule filling, that is, the direct filling agent, but most drugs, fluidity and other aspects of the problem, need to add certain diluents, lubricants and other excipients to meet the content or clinical drug requirements. Sucrose, lactose, microcrystalline cellulose, modified starch, silicon dioxide, magnesium stearate, talcum powder, high-performance lubricating powder, etc., can generally be added to improve the fluidity of the powder or avoid stratification. It can also be filled with excipients after granulation. Capsule specification selection and sets and seal: quantity need to choose according to the empty capsule drug specifications, doses of drugs in accordance with the relevant provisions on behalf of the empty capsule low capacity to choose, but then decided to first according to the empirical test and a common approach is to use material

Discoloration or discoloration of the press Reasons for discoloration or surface coloration and corresponding measures are as follows: (1) The excipients used in the compound preparation have a large color difference and are not overfinely ground or mixed, which is easy to produce freckles. This needs to be redone. The lubricants used for stamping can only be improved if they are carefully screened and mixed with the particles. (2) The particles are very hard, or when the particles of the color plate are not uniformly dense, it is easy to produce spots. In this case, the granules must be looser. The colored pellets are made of ethanol without starch as a wetting agent. The granules are uniform in thickness, fixed, and the tablets are not prone to blemishes. (3) In the compaction process, too much scaling will fall on the particles and move along with scaling, resulting in oil spots. The upper punch can be fitted with a layer of rubber band to prevent oil dirt from entering

Blister packaging for the application of milk tablets Milk slice is a product made of milk powder, vegetable cream, whey powder and sucrose after extrusion. At present, the vast majority of milk tablets are packaged as flat blister packs, which play an important role in storage and transportation. The packaging of blister plastic, also known as aluminum-plastic packaging (pressure packaging), is made by blanking and cutting the contents of the blister under certain pressure, temperature and time to form a vacuum (breathing) blister plastic or aluminum blister plastic shape, seal and substrate. Most of the covering materials are aluminum foil roll electrolytic aluminum. It is the most widely used metal material in packaging, non-toxic and tasteless, with excellent moistureproof, moistureproof, preservation, light resistance, so that the contents get more effective protection. After single-sided printing, the aluminum foil is coated with a protective layer, and the unprinted alumin