The making of empty capsules Gelatin is the main raw material for the preparation of capsule materials. There are also two types of gelatin, AB, acidic gelatin and basic gelatin. Gelatin comes from different sources and has different hardness, so it makes sense to use it together. In addition to gelatin, appropriate excipients should be prepared to ensure the quality of the capsules. The production process of empty capsule can be divided into six processes: sol, billet making, drying, extraction, cutting and finishing, most of which are completed by automatic production line. According to the national standard, the production of hollow capsule is divided into three degrees, namely, the first-class mechanism empty capsule, the first-class (empty capsule used for filling machine) and the qualified quality (empty capsule filled only by hand). The physical and chemical properties and bacteriological examination standards of the capsules were also specified. The preparation technol

Work analysis of tablet press High speed press is still a normal press, but the basic principle of the operation of the press is similar, the working principle of the press including filling, quantitative, prepressing, main pressure, and so on. Upper and lower die have burst disk drive, up and down along the guide movement from left to right, respectively, when the punch movement to fill section, upward movement of the punch movement around the forced feeder, at the same time, the role of the punch under the CAM adjustment moves down, on the surface and form a cavity die, the rotor's dust particles filled cavity, after filling the cavity, CAM punching form too much. The press press punch continues to move, while the lower punch gradually moves upwards, CAM particle filling, and excessive dispersion in the cavity are the average quantization of the extrusion die hole. Quantized partial filling, the upper surface of the filling CAM is horizontal, as long as the punch maintains horizon

Flat plate blister packaging machine Plate type blister packaging machine process flow and work plan: the formation of a plastic board preheater heating softening to plastic shapes, the steps of the servo traction device sent to the plate forming station, use compressed air to soften plastic blow molding or pressure blowing into the blister, filling packing blister of filling material feeder, then go to plane sealing device, and appropriate temperature, the pressure will be sent to board plastic and aluminum foil sealing, sent to the typing, stamping and punching device, with batch number, the broken line pressure, cutting into a regulation the size of the plate. The hard sheet of molding plastic is rolled, preheated, blown, packaged, sealed, coated aluminum foil, batch number, wire breaking pressure, step by step, pressure cutting, waste collection and so on. In recent years, some drugs have been needed in light-proof packaging, and a new packaging substrate, aluminum foil, has emer

Hygroscopic problem of capsule filling powder The hygroscopicity of the powder is a manifestation of the affinity between the material molecules and the water molecules, which is caused by the diffusion of the water molecules into the inner layer of the drug through the gas-liquid interface. The water content of a solid preparation is an important factor affecting its stability, because water content is the medium in which chemical reactions take place. The higher the water content, the faster the reaction. At the same time, the hygroscopic ability of the drug is also related to the relative humidity of the environment. The higher the relative humidity of the environment, the more readily the drug absorbs water. According to the types of raw materials added in the package of Chinese medicine components, it can be divided into three types: Chinese medicine extraction, complete Chinese medicine extraction and whole Chinese medicine powder. The extraction and purification methods of Ch

Press die for sheet pressing machine The die is an important part of the tablet press. Common faults in use include: punching rod wear, replacement, mainly due to too much pressure, punch bend affects the weight difference of tablets, need to be replaced. If the feeder is worn or not installed correctly, the bottom turntable of the feeder is worn closely to the plane, and the distance between the feeder's position and the bottom of the feeder and the bottom of the turntable is 0.05-0.1mm. Part of the caps on the head are not taken out in the feeder, which may cause wear or even damage to the machine in the stamping process. The pressure should not be too large, the machine should not be overloaded, found fault in time to deal with. For example, if detonation or beam wear occurs during stamping, replace the detonation or repair the replacement head. After replacing the feeder, clean the machine and separate the powder from the bottom. Improper installation of feeding machine caused rot

Material of blister packing machine In the pharmaceutical packaging material industry, the ex-factory aluminum foil is often called the original aluminum foil or the original foil. Aluminum has the advantages of abundant resources, low price and convenient processing. Aluminum foil is a metal used in packaging medical products. Aluminum foil is non-toxic and tasteless, with good electrical conductivity and opaque light, very resistant to humidity, endurance and the smell of protective gas, can more effectively protect the packaging of drugs, aluminum foil packaging is a metal film can not be evaporated, there are special coated special film can not be completely replaced. In the field of modern packaging binding, almost all soft packaging composite materials that need impervious to light or high barrier are made of aluminum foil as barrier layer. Because aluminum foil has the above advantages, light weight, high strength, good printing effect, can be printed on a variety of words or

The problem of empty capsule filling machine The main reasons for the occurrence of empty capsules in the production process may include: small capsules in the capsule shell, abnormal waste removal of the capsule filling machine, failure of the particle sensor, etc. There are small capsules in the capsule shell of the filling machine, and the scavenging function of the capsule filling machine cannot be eliminated. In order to ensure that the empty capsules do not enter the next process, the polishing machine can also be used to remove the empty capsules. Abnormal filling machines with abnormal function points, improper space between the waste suction nozzle and modules, and leakage of the suction line connecting the line may lead to abnormal results, as long as confirmed before production. Sensor failure cannot timely prevent dust recording in the distribution of the measuring plate, resulting in the lack of powder in the mold hole measuring plate and the production of empty sac. D

The problems and methods of the tablet press The disintegration delay in the tablet pressing process may occur in the tablet pressing machine, which means the disintegration time exceeds the pharmacopoeia. Reasons for disintegrating delay: insufficient amount of disintegrating agent; high viscosity of adhesive; high amount of hydrophobic lubricant; high pressure; high hardness of tablet. Solution: choose good disintegrating agent, or increase the dosage, reduce the adhesive dosage, or replace the adhesive with small viscosity, add hydrophilic lubricant, adjust the pressure of the tablet press. Reasons for the big difference in weight: particle size, flow rate, not flexible down and rise, too much or too little charge. Solution: re-granulation, add flow AIDS, stop check, adjust the hopper to make the same amount of packing. Discoloration or spot refers to the change of hydrochloric acid on the surface of the tablet or the appearance of different color spots, pitting.

Conditions for filling capsules Oil-based drugs and low melting point drugs are most suitable for the production of soft capsules. Oily drugs are all liquid or semi-solid at room temperature, which are pretreated at room temperature and commonly used in the preparation of adsorption, treatment and other processes. Auxiliary materials such as the addition of a large number of adsorbents, during the preparation process, the drugs that are easy to dry and heat become free or exudate, and the main drugs become ineffective, affecting the efficiency. And gelatin soft capsule is oily drug and low melting drug in the solution or filler or emulsion drops, general excipients are adsorbed, can not only preparation miniaturization, but also can avoid the product how to release and exudate. Such as vitriolic oil pills, vitriolic oil pills, anti-inflammatory drugs, etc. Sensitive to light, unstable at humidity and high temperatures, readily oxidizable drugs can be made into soft capsules. Some

Blister packaging technology for drugs Product blister packaging refers to the product filled with drugs, through vacuum (suction) bubble or compression molding blister, using aluminum foil, under a certain pressure, under a certain temperature and time conditions, together with the base material heat sealed and formed. Blister packaging, also known as drug blister packaging, is one of the main forms of drug packaging, suitable for tablets, capsules, suppositories, pills and other solid preparations of mechanical packaging. The rise of blister packaging in China was as early as the 1930s, when the bubble packaging of drugs first developed vigorously in Europe and was gradually promoted and used in the world. Later, China introduced medical blister machinery and equipment, but still needed to import foam packaging materials such as aluminum foil. Until the foreign advanced blister packaging material production of aluminum coating printing production, first introduced the National Med